منابع مشابه
Melanogenesis Inhibitor(s) from Phyla nodiflora Extract
Overexpression of tyrosinase can cause excessive production of melanin and lead to hyperpigmentation disorders, including melasma and freckles. Recently, agents obtained from plants are being used as alternative medicines to downregulate tyrosinase synthesis and decrease melanin production. Phyla nodiflora Greene (Verbenaceae) is used as a folk medicine in Taiwanese for treating and preventing ...
متن کاملThe calcium store sensor , STIM 1 , recipro - cally controls
Question: Why do excitable cells express store-operated Ca channels and nonexcitable cells express voltage-gated Ca channels (VGCCs)? Background: Ca release-activated Ca (CRAC) Orai channels increase intracellular Ca concentrations in response to depletion of endoplasmic reticulum (ER) Ca stores via a stromal interaction molecule 1 (STIM1)-dependent mechanism. VGCCs, suchas Cav1.2 channels, inc...
متن کاملC ov er s to ry 1
Corresponding author: Ueli Aebi Phone: +41 61 267 2260 Fax: +41 61 267 2109 E-mail: [email protected] Rheumatic diseases – the burden of aging During the past century the average life expectancy has increased by nearly 20 years. While this definitely represents an unprecedented achievement, this gain is still on the expense of numerous diseases that are becoming more prominent in the elderly....
متن کاملUnlocking SOAR releases STIM.
A crucial component of the receptor-evoked Ca(2+) signal is Ca(2+) influx mediated by the store-operated Ca(2+) channels (SOCs). The molecular makeup of one SOC is the endoplasmic reticulum (ER) Ca(2+) sensor STIM1 and the pore-forming Orai1. Ca(2+) release from the ER leads to co-clustering of STIM1 and Orai1 to activate Orai1. The short STIM1 SOAR/CAD domain (STIM1 Orai1-activating region/CRA...
متن کاملGPU Programming Using C++ AMP
Nowadays, a challenge for programmers is to make their programs better. The word "better" means more simple, portable and much faster in execution. Heterogeneous computing is a new methodology in computer science field. GPGPU programming is a new and challenging technique which is used for solving problems with data parallel nature. In this paper we describe this new programming methodology wit...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2018
ISSN: 0261-4189,1460-2075
DOI: 10.15252/embj.201899047